{"id":569,"date":"2026-08-11T19:53:42","date_gmt":"2026-08-11T19:53:42","guid":{"rendered":"https:\/\/syrian-biomedica.com\/kinana-adnan\/"},"modified":"2026-08-15T09:03:35","modified_gmt":"2026-08-15T09:03:35","slug":"kinana-adnan","status":"publish","type":"page","link":"https:\/\/syrian-biomedica.com\/ar\/kinana-adnan\/","title":{"rendered":"Kinana Adnan"},"content":{"rendered":"<h1><strong>Kinana Adnan<\/strong><\/h1>\n<h1>Kinana Adnan, Dr.Ranwa Alsayed<\/p>\n<p>Faculty of Pharmacy, Damascus University.<\/h1>\n<div>\n<p><strong>The Effect of Vitamin D and Magnesium Co-supplementation on Glycemic Control in Patients with Type 2 Diabetes and Prediabetes: A Systematic Review and Critical Narrative Synthesis of Evidence<\/strong><\/p>\n<\/div>\n<div>\n<p><strong><u>Background<\/u>:<\/strong><\/p>\n<p>Type 2 Diabetes Mellitus (T2DM) constitutes a growing global burden, necessitating effective adjunctive therapies. Magnesium acts as an obligate catalytic cofactor for vitamin D activation, while active vitamin D maintains pancreatic beta-cell function. Although widely discussed, the true clinical efficacy of their co-administration\u2014independent of competitive mineral interference\u2014requires rigorous evaluation.<\/p>\n<\/p>\n<p><strong><u>Objectives<\/u>:<\/strong><\/p>\n<p>To evaluate the clinical efficacy of combined oral vitamin D and magnesium supplementation on glucose homeostasis indices in patients with T2DM and prediabetes, isolating their synergistic effect from competitive confounders.<\/p>\n<\/p>\n<p><strong><u>Methods<\/u>:<\/strong><\/p>\n<p>Conducted following PRISMA 2020 guidelines and registered in PROSPERO, a comprehensive search of major medical databases identified completed and ongoing randomized controlled trials (RCTs). Stringent confounder-driven exclusion criteria were applied to eliminate competitive electrolytes (specifically calcium and zinc). Methodological quality and evidence certainty were critically appraised using RoB 2 and GRADE tools.<\/p>\n<\/p>\n<p><strong><u>Results<\/u>:<\/strong><\/p>\n<p>Screening revealed a stark research gap: no completed confounder-free RCTs directly compared combined versus isolated administration. Consequently, one completed placebo-controlled RCT (N=100) and three ongoing trial protocols were included. The completed trial demonstrated that the combined intervention achieved a statistically significant reduction in fasting blood glucose with a mean difference of 33.62 mg\/dL (95% CI: [7.63, 59.61], p = 0.01) and HbA1c with a mean difference of 0.83% (95% CI: [0.034, 1.63], p = 0.04) compared to placebo. Despite the low risk of bias, overall GRADE certainty was rated as \u201clow\u201d due to statistical imprecision from the small available sample size.<\/p>\n<\/p>\n<p><strong><u>Conclusion<\/u>:<\/strong><\/p>\n<p>Preliminary evidence supports the high physiological and clinical plausibility of this dual synergy in regulating glucose homeostasis. To formulate definitive clinical recommendations, future research must bridge this methodological gap by adopting a four-arm experimental design. Furthermore, this gap provides a compelling justification for conducting localized clinical trials.<\/p>\n<\/p>\n<p><strong><u>Keywords<\/u>:<\/strong><\/p>\n<p>Type 2 Diabetes; Vitamin D; Magnesium; Systematic Review; Glucose Homeostasis<\/p>\n<\/div>\n<p><!--more--><br \/>\n<!-- {\"type\":\"layout\",\"children\":[{\"name\":\"Terms\",\"type\":\"section\",\"props\":{\"image_position\":\"center-center\",\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"\",\"width\":\"small\"},\"children\":[{\"type\":\"row\",\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-1\"},\"children\":[{\"type\":\"headline\",\"props\":{\"content\":\"<strong>Kinana Adnan<\\\/strong>\",\"image_align\":\"left\",\"image_margin\":\"xsmall\",\"margin_top\":\"remove\",\"title_element\":\"h1\",\"title_style\":\"heading-medium\"}},{\"type\":\"headline\",\"props\":{\"content\":\"Kinana Adnan, Dr.Ranwa Alsayed<br \\\/><br \\\/>Faculty of Pharmacy, Damascus University.\",\"title_element\":\"h1\",\"title_style\":\"text-small\"}},{\"type\":\"headline\",\"props\":{\"content\":\"\n\n<p><strong>The Effect of Vitamin D and Magnesium Co-supplementation on Glycemic Control in Patients with Type 2 Diabetes and Prediabetes: A Systematic Review and Critical Narrative Synthesis of Evidence<\\\/strong><\\\/p>\",\"image_align\":\"left\",\"image_margin\":\"xsmall\",\"margin_bottom\":\"remove\",\"title_color\":\"muted\",\"title_element\":\"div\",\"title_style\":\"h4\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p><strong><u>Background<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>Type 2 Diabetes Mellitus (T2DM) constitutes a growing global burden, necessitating effective adjunctive therapies. Magnesium acts as an obligate catalytic cofactor for vitamin D activation, while active vitamin D maintains pancreatic beta-cell function. Although widely discussed, the true clinical efficacy of their co-administration\\u2014independent of competitive mineral interference\\u2014requires rigorous evaluation.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><strong><u>Objectives<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>To evaluate the clinical efficacy of combined oral vitamin D and magnesium supplementation on glucose homeostasis indices in patients with T2DM and prediabetes, isolating their synergistic effect from competitive confounders.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><strong><u>Methods<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>Conducted following PRISMA 2020 guidelines and registered in PROSPERO, a comprehensive search of major medical databases identified completed and ongoing randomized controlled trials (RCTs). Stringent confounder-driven exclusion criteria were applied to eliminate competitive electrolytes (specifically calcium and zinc). Methodological quality and evidence certainty were critically appraised using RoB 2 and GRADE tools.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><strong><u>Results<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>Screening revealed a stark research gap: no completed confounder-free RCTs directly compared combined versus isolated administration. Consequently, one completed placebo-controlled RCT (N=100) and three ongoing trial protocols were included. The completed trial demonstrated that the combined intervention achieved a statistically significant reduction in fasting blood glucose with a mean difference of 33.62 mg\\\/dL (95% CI: [7.63, 59.61], p = 0.01) and HbA1c with a mean difference of 0.83% (95% CI: [0.034, 1.63], p = 0.04) compared to placebo. Despite the low risk of bias, overall GRADE certainty was rated as \\u201clow\\u201d due to statistical imprecision from the small available sample size.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><strong><u>Conclusion<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>Preliminary evidence supports the high physiological and clinical plausibility of this dual synergy in regulating glucose homeostasis. To formulate definitive clinical recommendations, future research must bridge this methodological gap by adopting a four-arm experimental design. Furthermore, this gap provides a compelling justification for conducting localized clinical trials.<\\\/p>\\n\n\n<p><\\\/p>\\n\n\n<p><strong><u>Keywords<\\\/u>:<\\\/strong><\\\/p>\\n\n\n<p>Type 2 Diabetes; Vitamin D; Magnesium; Systematic Review; Glucose Homeostasis<\\\/p>\",\"margin\":\"default\"}}]}]}]}],\"version\":\"4.5.32\"} --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kinana Adnan Kinana Adnan, Dr.Ranwa Alsayed Faculty of Pharmacy, Damascus University. The Effect of Vitamin D and Magnesium Co-supplementation on Glycemic Control in Patients with Type 2 Diabetes and Prediabetes: A Systematic Review and Critical Narrative Synthesis of Evidence Background: Type 2 Diabetes Mellitus (T2DM) constitutes a growing global burden, necessitating effective adjunctive therapies. Magnesium [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_et_pb_custom_css":""},"class_list":["post-569","page","type-page","status-publish","hentry"],"_et_pb_custom_css":"","_links":{"self":[{"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/pages\/569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/comments?post=569"}],"version-history":[{"count":2,"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/pages\/569\/revisions"}],"predecessor-version":[{"id":603,"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/pages\/569\/revisions\/603"}],"wp:attachment":[{"href":"https:\/\/syrian-biomedica.com\/ar\/wp-json\/wp\/v2\/media?parent=569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}